Efficacy of Lactobacillus reuteri Supplementation in Eradication of H. pylori: A Comparison Study with Triple Drug Therapy

Helicobacter pylori (H. pylori) infections affect roughly one-half of the world’s population. Although many standard regimens, including triple-drug therapy, eradicate H. pylori, success rate and efficacy have been declining due to associated side effects symptom severity. The addition probiotics a regimen can considerably increase eradication rates. objective is find probiotic Lactobacillus reuteri (L. reuteri) in eradicating human infection effect on symptoms regression with triple therapy. This prospective interventional study was conducted 90 pylori-positive patients. 45 patients received treatment (group-I) for 14 days. Another combination therapy L. (group-II) After completion treatment, status evaluated using 13-C Urea-Breath Test (UBT). Each subject interviewed validated Gastrointestinal Symptoms Rating Scale (GSRS) questionnaire record severity before after Group-II showed significantly higher (86.67%) than group-I (66.67%). absolute values 13C-UBT (group-I: 14.02± 5.4, group-II: 11.9±3.73) revealed that more substantial reduction Pylori load observed group II. Statistical analysis proved II had significant GSRS mean scores (baseline score: 15.39±4.52 end 5.33±2.34) compared 14.47±3.67 9.86±4.78). Addition has reduced drug except bloating. In conclusion, supplementation improved intensity gastrointestinal also related effects.